2-(Bromomethyl)pyridine hydrobromide → HCID 58755929, compound

HRID 1625562Notes

Reaction equation

HRID 1625562 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:10][C:11](=[S:14])[NH:12][N:13]=2)=[C:5]([CH3:15])[CH:4]=1)[CH3:2].Br.Br[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=1>>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:13][N:12]=[C:11]([S:14][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=3)[N:10]=2)=[C:5]([CH3:15])[CH:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 27347202-(Bromomethyl)pyridine hydrobromideHCID 178435881HCID 178435881, compound

Product 1

HCID 58755929HCID 58755929, compoundYield 39%

Procedure

Prepared in a similar manner to example 1 using 5-(4-ethyl-2-methylphenyl)-2H-1,2,4-triazole-3(4H)-thione (example 10a) and 2-(bromomethyl)pyridine hydrobromide. Yield 39%. 1H NMR (300 MHz, dMSO): δ 1.17-1.22 (t, 3H), 2.46 (s, 3H), 2.60-2.64 (dd, 2H), 4.50 (s, 2H), 7.14-7.18 (m, 2H), 7.27-7.29 (m, 1H), 7.47-7.49 (d, 1H), 7.58 (bd, 1H), 7.72-7.77 (m, 1H), 8.50-8.51 (d, 1H). MS (M+H, 311).

Sources & evidence

ORD record
ord-ae0c47bba68c4010bae1a4719eddaeaf
Source dataset
uspto-grants-2014_07
Patent number
US08784782B2

Reaction notes

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