反应详情

[2′-[(Cyclopropanecarbonyl-ethyl-amino)-methyl]-4′-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetic acid (26.0 g, 53.2 mmol) was dissolved in ethanol (180 mL), sodium hydroxide (53.2 mL, 1N aq.) was added and the reaction was stirred at room temperature for 1 hour. The solution was filtered to remove solid impurities then concentrated. The residue was dissolved in water (˜150 mL) then frozen and lyophilized to afford the title compound.

1. filtrationThe solution was filtered
2. customto remove solid impurities
3. concentrationthen concentrated
4. dissolutionThe residue was dissolved in water (˜150 mL)
5. temperaturethen frozen