HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-pentynoate → HCID 58481154, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-pentynoate | HCID 543061 | — |
| Reactant | 4-Bromo-2-nitrobenzaldehyde | HCID 608099 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Product | HCID 58481154 | HCID 58481154 | — |
Reaction Steps
A mixture of 4-bromo-2-nitrobenzaldehyde (460 mg), Pd(PPh3)2Cl2 (70 mg), and CuI (38 mg), methyl pent-4-ynoate (269 mg) in TEA(5.0 mL) was stirred at room temperature until the reaction was completed. The crude residue was purified by a silica gel flash chromatography (15% EtOAc in hexanes), affording methyl 5-(4-formyl-3-nitrophenyl)pent-4-ynoate. ESI-MS m/z 262.23 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08785151B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-63db8492dd324d418d45b869fffe641a |
| Source note | uspto-grants-2014_07 |