HCID 58481154, compound → HCID 58481179, compound

HRID 1625703Notes

Reaction equation

HRID 1625703 reaction equation
[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]#[C:10][CH2:11][CH2:12][C:13]([O:15][CH3:16])=[O:14])=[CH:5][C:4]=1[N+:17]([O-])=O)=[O:2].[H][H]>CO.[Pd]>[NH2:17][C:4]1[CH:5]=[C:6]([CH2:9][CH2:10][CH2:11][CH2:12][C:13]([O:15][CH3:16])=[O:14])[CH:7]=[CH:8][C:3]=1[CH:1]=[O:2]

Participants

5

Reactant 2

HCID 58481154HCID 58481154, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 58481179HCID 58481179, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Methyl 5-(4-formyl-3-nitrophenyl)pent-4-ynoate (522 mg) was reduced by 5% Pd/C (53 mg) in MeOH with hydrogen balloon at room temperature. Filtration followed by concentration under reduced pressure afforded methyl 5-(3-amino-4-formylphenyl)pentanoate. MS-ESI m/z 236.28 (MH+).

Workup

  1. filtrationFiltration
  2. concentrationfollowed by concentration under reduced pressure

Sources & evidence

ORD record
ord-791422cd145a420da25bcc0c1fef67b2
Source dataset
uspto-grants-2014_07
Patent number
US08785151B2

Reaction notes

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