2-(2'-Thienyl)pyridine → 5-Bromo-2-chlorophenyl-5-(2-pyridyl)-2-thienylmethanol

HRID 1625789Notes

Reaction equation

HRID 1625789 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[S:8][CH:9]=[CH:10][CH:11]=1.[Br:12][C:13]1[CH:14]=[CH:15][C:16]([Cl:21])=[C:17]([CH:20]=1)[CH:18]=[O:19]>>[Br:12][C:13]1[CH:14]=[CH:15][C:16]([Cl:21])=[C:17]([CH:18]([C:9]2[S:8][C:7]([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=3)=[CH:11][CH:10]=2)[OH:19])[CH:20]=1

Participants

3

Reactant 2

HCID 768322-(2'-Thienyl)pyridineHCID 106089255-Bromo-2-chlorobenzaldehyde

Product 1

HCID 666073255-Bromo-2-chlorophenyl-5-(2-pyridyl)-2-thienylmethanol

Procedure

2-(2-Pyridyl)thiophene and 5-bromo-2-chlorobenzaldehyde obtained in Reference Example 16-(1) were treated in a manner similar to Reference Example 7-(1) to give 5-bromo-2-chlorophenyl-5-(2-pyridyl)-2-thienylmethanol as colorless powder. APCI-Mass m/Z 380/382 (M+H).

Sources & evidence

ORD record
ord-c48cdbb3395648748a5116ef10bd5a45
Source dataset
uspto-grants-2014_07
Patent number
US08785403B2

Reaction notes

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