2-Chlorothiophene → HCID 66608266, compound

HRID 1625791Notes

Reaction equation

HRID 1625791 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([I:11])=[C:6]([CH:10]=1)[C:7](O)=O.[Cl:12][C:13]1[S:14][CH:15]=[CH:16][CH:17]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([I:11])=[C:6]([CH2:7][C:15]2[S:14][C:13]([Cl:12])=[CH:17][CH:16]=2)[CH:10]=1

Participants

3

Reactant 2

HCID 72992-ChlorothiopheneHCID 3029395-Bromo-2-iodobenzoic acid

Product 1

HCID 66608266HCID 66608266, compound

Procedure

5-Bromo-2-iodobenzoic acid (see Jorg Frahn, A.-Dieter Schluter Synthesis 1997, 1301-1304) and 2-chlorothiophene were treated in a manner similar to Reference Example 5 to give 5-bromo-1-(5-chloro-2-thienylmethyl)-2-iodobenzene as colorless oil.

Sources & evidence

ORD record
ord-3e31f2e069334195b2a578dbbb34ba4c
Source dataset
uspto-grants-2014_07
Patent number
US08785403B2

Reaction notes

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