5-Bromo-2-chlorobenzaldehyde → HCID 66607628, compound

HRID 1625807Notes

Reaction equation

HRID 1625807 reaction equation
[CH3:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]2[S:6][CH:7]=[CH:8][C:4]=2[CH:3]=1.[Br:12][C:13]1[CH:14]=[CH:15][C:16]([Cl:21])=[C:17]([CH:20]=1)[CH:18]=O>>[Br:12][C:13]1[CH:14]=[CH:15][C:16]([Cl:21])=[C:17]([CH2:18][C:7]2[S:6][C:5]3[C:9]([CH3:11])=[CH:10][C:2]([CH3:1])=[CH:3][C:4]=3[CH:8]=2)[CH:20]=1

Participants

3

Reactant 2

HCID 106089255-Bromo-2-chlorobenzaldehydeHCID 10773301HCID 10773301, compound

Product 1

HCID 66607628HCID 66607628, compound

Procedure

5,7-Dimethylbenzo[b]thiophene (see Yoshimura, Y. et al., J. Med. Chem. 43 (2000) 2929-2937) and 5-bromo-2-chlorobenzaldehyde obtained in Reference Example 16-(1) were treated in a manner similar to Reference Example 7 to give the target compound.

Workup

  1. additionwere treated in a manner similar to Reference Example 7
  2. customto give the target compound

Sources & evidence

ORD record
ord-d487ca061b334b519fafc85cb9432921
Source dataset
uspto-grants-2014_07
Patent number
US08785403B2

Reaction notes

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