Benzo(B)Thiophene → HCID 66608282, compound

HRID 1625817Notes

Reaction equation

HRID 1625817 reaction equation
CON(C)[C:4](=O)[C:5]1[CH:10]=[C:9]([Br:11])[CH:8]=[CH:7][C:6]=1[C:12]([F:15])([F:14])[F:13].[CH:18]1[CH:19]=[CH:20][C:21]2[S:26][CH:25]=[CH:24][C:22]=2[CH:23]=1>>[S:26]1[C:25]([CH2:4][C:5]2[CH:10]=[C:9]([Br:11])[CH:8]=[CH:7][C:6]=2[C:12]([F:15])([F:14])[F:13])=[CH:24][C:22]2[CH:23]=[CH:18][CH:19]=[CH:20][C:21]1=2

Participants

3

Reactant 2

HCID 7221Benzo(B)ThiopheneHCID 86028268HCID 86028268, compound

Product 1

HCID 66608282HCID 66608282, compound

Procedure

The above N-methoxy-N-methyl-5-bromo-2-trifluoromethylbenzamide and thianaphthene were treated in a manner similar to Reference Example 45 to give 1-(Benzo[b]thiophen-2-ylmethyl)-5-bromo-2-trifluoromethylbenzene as a colorless solid. ESI-Mass m/Z 369/371 (M−H).

Sources & evidence

ORD record
ord-e3b678c378854dceaae7a99dc7216475
Source dataset
uspto-grants-2014_07
Patent number
US08785403B2

Reaction notes

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