2-Iodothiophene → 2-(4-Methylphenyl)thiophene

HRID 1625818Notes

Reaction equation

I[C:2]1[S:3][CH:4]=[CH:5][CH:6]=1.[CH3:7][C:8]1[CH:13]=[CH:12][C:11](B(O)O)=[CH:10][CH:9]=1>>[CH3:7][C:8]1[CH:13]=[CH:12][C:11]([C:2]2[S:3][CH:4]=[CH:5][CH:6]=2)=[CH:10][CH:9]=1

Participants

Reactant 2

HCID 189212-Iodothiophene

HCID 79799Tolylboronic acid

Product 1

HCID 41284662-(4-Methylphenyl)thiophene

Procedure

2-Iodothiophene and 4-methylphenylboronic acid were treated in a manner similar to Reference Example 26-(2) to give 2-(4-methylphenyl)thiophene as colorless crystals. APCI-Mass m/Z 175 (M+H).

Sources & evidence

ORD record: ord-4359239a6b0b4ef68d871000ff66bd37
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08785403B2

Reaction notes

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