2-Iodothiophene → 2-(4-Fluorophenyl)thiophene

HRID 1625820Notes

Reaction equation

I[C:2]1[S:3][CH:4]=[CH:5][CH:6]=1.[F:7][C:8]1[CH:13]=[CH:12][C:11](B(O)O)=[CH:10][CH:9]=1>>[F:7][C:8]1[CH:13]=[CH:12][C:11]([C:2]2[S:3][CH:4]=[CH:5][CH:6]=2)=[CH:10][CH:9]=1

Participants

Reactant 2

HCID 189212-Iodothiophene

HCID 2856454-Fluorophenylboronic acid

Product 1

HCID 218947832-(4-Fluorophenyl)thiophene

Procedure

2-Iodothiophene and 4-fluorophenylboronic acid were treated in a manner similar to Reference Example 26-(2) to give 2-(4-fluorophenyl)thiophene as colorless powder.

Sources & evidence

ORD record: ord-e2f1b4085e31479093bf644d750fabef
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08785403B2

Reaction notes

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