5-Bromo-2-methylbenzoic acid → HCID 66608311, compound

HRID 1625834Notes

Reaction equation

HRID 1625834 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)[CH:5]=[CH:6][CH:7]=1.[Br:13][C:14]1[CH:15]=[CH:16][C:17]([CH3:23])=[C:18]([CH:22]=1)[C:19](O)=O>>[Br:13][C:14]1[CH:15]=[CH:16][C:17]([CH3:23])=[C:18]([CH2:19][C:10]2[S:9][C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=3)=[CH:12][CH:11]=2)[CH:22]=1

Participants

3

Reactant 2

HCID 3460045-Bromo-2-methylbenzoic acidHCID 22486407HCID 22486407, compound

Product 1

HCID 66608311HCID 66608311, compound

Procedure

2-(3-Fluorophenyl)thiophene obtained in Reference Example 75-(1) and 5-bromo-2-methylbenzoic acid obtained in Reference Example 4-(1) were treated in a manner similar to Reference Example 5 to give the target compound.

Workup

  1. addition4-(1) were treated in a manner similar to Reference Example 5
  2. customto give the target compound

Sources & evidence

ORD record
ord-032dd2da37e441dd9b38efa3ca62d2b7
Source dataset
uspto-grants-2014_07
Patent number
US08785403B2

Reaction notes

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