3-Bromoanisole → 2-(3-methoxyphenyl)thiophene

HRID 1625839Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5](Br)[CH:6]=[CH:7][CH:8]=1.[S:10]1[CH:14]=[CH:13][CH:12]=[C:11]1B(O)O>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[S:10][CH:14]=[CH:13][CH:12]=2)[CH:6]=[CH:7][CH:8]=1

Participants

Reactant 2

HCID 169713-Bromoanisole

HCID 27339602-Thiopheneboronic acid

Product 1

HCID 35641912-(3-methoxyphenyl)thiophene

Procedure

3-Methoxybromobenzene and thiophene-2-boronic acid were treated in a manner similar to Reference Example 26-(2) to give 2-(3-methoxyphenyl)thiophene as a yellow liquid. APCI-Mass m/Z 191 (M+H).

Sources & evidence

ORD record: ord-73eb8b706448441d80653a1b1d2be8b4
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08785403B2

Reaction notes

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