5-Phenylthiazole → 5-Bromo-2-chloro-1-(5-phenyl-2-thiazolylmethyl)benzene

HRID 1625848Notes

Reaction equation

HRID 1625848 reaction equation
[C:1]1([C:7]2[S:11][CH:10]=[N:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:12][C:13]1[CH:14]=[CH:15][C:16]([Cl:21])=[C:17]([CH:20]=1)[CH:18]=O>>[Br:12][C:13]1[CH:14]=[CH:15][C:16]([Cl:21])=[C:17]([CH2:18][C:10]2[S:11][C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[CH:8][N:9]=2)[CH:20]=1

Participants

3

Reactant 2

HCID 5952095-PhenylthiazoleHCID 106089255-Bromo-2-chlorobenzaldehyde

Product 1

HCID 666083225-Bromo-2-chloro-1-(5-phenyl-2-thiazolylmethyl)benzene

Procedure

The above 5-phenylthiazole and 5-bromo-2-chlorobenzaldehyde obtained in Reference Example 16-(1) were treated in a manner similar to Reference Example 100 to give 5-bromo-2-chloro-1-(5-phenyl-2-thiazolylmethyl)benzene as a yellow solid. APCI-Mass m/Z 364/366 (M+H).

Workup

  1. additionwere treated in a manner similar to Reference Example 100

Sources & evidence

ORD record
ord-1c73583fc7374a2ca8979396905a970f
Source dataset
uspto-grants-2014_07
Patent number
US08785403B2

Reaction notes

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