反应详情

The above 1-t-butoxycarbonyl-3-(4-ethylphenylmethyl)-1H-indazole (1.35 g) was dissolved in methanol (15 ml), and added thereto was 28% sodium methoxide solution (methanol solution, 1.0 ml), and the mixture was stirred at room temperature for one hour. Added thereto was an aqueous citric acid solution, and the mixture was extracted with ethyl acetate. The extract was washed successively with water and brine, and dried over magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was crystallized from hexane to give the desired 3-(4-ethylphenylmethyl)-1H-indazole (800 mg) as colorless crystals. APCI-Mass m/Z 237 (M+H).

1. additionadded
2. additionAdded
3. extractionthe mixture was extracted with ethyl acetate
4. washThe extract was washed successively with water and brine
5. dry with materialdried over magnesium sulfate
6. customThe solvent was evaporated under reduced pressure
7. customthe residue was crystallized from hexane