4-Bromoanisole → 2-(4-methoxyphenyl)thiophene

HRID 1625878Notes

Reaction equation

HRID 1625878 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=1.[S:10]1[CH:14]=[CH:13][CH:12]=[C:11]1B(O)O>>[CH3:9][O:8][C:5]1[CH:6]=[CH:7][C:2]([C:11]2[S:10][CH:14]=[CH:13][CH:12]=2)=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 77304-BromoanisoleHCID 27339602-Thiopheneboronic acid

Product 1

HCID 27694252-(4-methoxyphenyl)thiophene

Procedure

p-Bromoanisole and thiophene-2-boronic acid were treated in a manner similar to Reference Example 20-(1) to give 2-(4-methoxyphenyl)thiophene as a pale yellow solid. APCI-Mass m/Z 191 (M+H).

Sources & evidence

ORD record
ord-fc1e8a457a244078b53087225838df92
Source dataset
uspto-grants-2014_07
Patent number
US08785403B2

Reaction notes

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