4-Bromo-2-methylbenzoic acid → HCID 66607523, compound

HRID 1625879Notes

Reaction equation

HRID 1625879 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:10][CH:11]=[CH:12][CH:13]=2)=[CH:5][CH:4]=1.[Br:14][C:15]1[CH:23]=[CH:22][C:18]([C:19](O)=O)=[C:17]([CH3:24])[CH:16]=1>>[Br:14][C:15]1[CH:23]=[CH:22][C:18]([CH3:19])=[C:17]([CH2:24][C:11]2[S:10][C:9]([C:6]3[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=3)=[CH:13][CH:12]=2)[CH:16]=1

Participants

3

Reactant 2

HCID 995704-Bromo-2-methylbenzoic acidHCID 27694252-(4-methoxyphenyl)thiophene

Product 1

HCID 66607523HCID 66607523, compound

Procedure

The above 2-(4-methoxyphenyl)thiophene and 4-bromo-2-methylbenzoic acid obtained in Reference Example 4-(1) were treated in a manner similar to Reference Example 5 to give 5-bromo-1-(5-(4-methoxyphenyl)-2-thienylmethyl)-2-methylbenzene as a pale yellow solid. APCI-Mass m/Z 373/375 (M+H).

Workup

  1. addition4-(1) were treated in a manner similar to Reference Example 5

Sources & evidence

ORD record
ord-f8d686f29f62401a918b6d5ff4c8b739
Source dataset
uspto-grants-2014_07
Patent number
US08785403B2

Reaction notes

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