2-(2'-Thienyl)pyridine → 4-Bromo-1-fluoro-2-(5-(2-pyridyl)-2-thienylmethyl)naphthalene

HRID 1625898Notes

Reaction equation

HRID 1625898 reaction equation
[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([F:12])=[C:4]([CH:13]=O)[CH:3]=1.[N:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[C:21]1[S:22][CH:23]=[CH:24][CH:25]=1>>[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([F:12])=[C:4]([CH2:13][C:23]2[S:22][C:21]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][N:15]=3)=[CH:25][CH:24]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 768322-(2'-Thienyl)pyridineHCID 534400924-Bromo-1-fluoronaphthalene-2-carbaldehyde

Product 1

HCID 666078714-Bromo-1-fluoro-2-(5-(2-pyridyl)-2-thienylmethyl)naphthalene

Procedure

The above 4-bromo-1-fluoro-2-naphthaldehyde and 2-(2-pyridyl)thiophene were treated in a manner similar to Reference Example 120 to give the desired 4-bromo-1fluoro-2-(5-(2-pyridyl)-2-thienylmethyl)naphthalene as colorless powder. APCI-Mass m/Z 398/400 (M+H).

Sources & evidence

ORD record
ord-5c944b4fe2094773a351609ee974d2af
Source dataset
uspto-grants-2014_07
Patent number
US08785403B2

Reaction notes

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