Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | HCID 67175734 | HCID 67175734 | — |
| Reactant | HCID 178527881 | HCID 178527881 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 67324778 | HCID 67324778 | 12.6% |
Reaction Steps
113 mg of cesium carbonate and 100 mg of 5-methanesulfonyl-7-propoxy-2-(3-methyl-phenyl)-oxazolo[5,4-d]pyrimidine were added to a solution of 34 mg of 2-mercaptothiazole in 3 ml of DMF. The mixture was heated to 100° C. in a microwave reactor for 15 min. After cooling and filtration, the solvent was distilled off in vacuo, and the product was isolated via preparative HPLC to yield 14 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08785439B2 |
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| Source dataset | uspto-grants-2014_07 |
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| ORD ID | ord-22ade318db65446fb3212231be50c636 |
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| Source note | uspto-grants-2014_07 |
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