Boron tribromide → HCID 136132570, compound

Participants

Reaction Steps

1.0 ml of a 1 M solution of boron tribromide in dichloromethane was slowly added to an ice-cooled solution of 145 mg of 5-(2-fluoro-phenoxy)-2-(4-methoxy-3,5-dimethyl-phenyl)-7-propoxy-oxazolo[5,4-d]pyrimidine in 8 ml of dichloromethane. The mixture was stirred for 2 h while maintaining ice cooling, and another 1 h at room temperature. Then a saturated solution of sodium hydrogencarbonate was carefully added. Extraction with dichloromethane, drying over sodium sulfate, filtration and removal of the solvent in vacuo gave 126 mg of the title compound.

Provenance & Evidence