Lithium borohydride → HCID 71009224, compound

Participants

Reaction Steps

Starting from (1R,2R)-2-[(R)-2-ethoxycarbonyl-2,2-difluoro-1-methyl-1-((R)-2-methyl-propane-2-sulfinylamino)-ethyl]-cyclopropanecarboxylic acid tert-butylester (intermediate J3.2) the reduction with lithium borohydride yielded the (1R,2R)-2-[(R)-2,2-difluoro-3-hydroxy-1-methyl-1-((R)-2-methyl-propane-2-sulfinylamino)-propyl]-cyclopropanecarboxylic acid tert-butyl ester (81% yield) as a colorless oil. MS (ISP): m/z=370.1 [M+H]+.

Provenance & Evidence