Lithium borohydride → HCID 71009034, compound

Participants

Reaction Steps

Starting from (1S,2S)-2-[(R)-2-ethoxycarbonyl-2,2-difluoro-1-methyl-1-((R)-2-methyl-propane-2-sulfinylamino)-ethyl]-cyclopropanecarboxylic acid tert-butylester (intermediate J3.3) the reduction with lithium borohydride yielded the (1S,2S)-2-[(R)-2,2-difluoro-3-hydroxy-1-methyl-1-((R)-2-methyl-propane-2-sulfinylamino)-propyl]-cyclopropanecarboxylic acid tert-butyl ester (80% yield) as a white solid. MS (ISP): m/z=370.2 [M+H]+.

Provenance & Evidence