HRID1626117

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3406

4-Methylpyrazole

C4H6N2

结构：COc1ccc(C(NC2=N[C@](C)(c3cc(Br)ccc3F)[C@@H](F)CO2)(c2ccccc2)c2ccc(OC)cc2)cc1

HCID71008920

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C(NC2=N[C@](C)(c3cc(-n4cc(C)cn4)ccc3F)[C@@H](F)CO2)(c2ccccc2)c2ccc(OC)cc2)cc1

HCID71008818

未命名化合物

收率 28%

PROCEDURE

实验过程

In a manner analogous to that described in Example 3 a), the amination of [bis-(4-methoxy-phenyl)-phenyl-methyl]-[(4R,5R)-4-(5-bromo-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-amine (intermediate C4.3) with 4-methyl-1H-pyrazole yielded the title compound (28% yield) as a white foam. MS (ISP): m/z=609.2 [M+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-66f95975831b486f8a3a9bf7c7b872d3
来源数据集: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08785436B2
来源说明: uspto-grants-2014_07

反应 SMILES

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([NH:24][C:25]2[O:26][CH2:27][C@H:28]([F:40])[C@:29]([C:32]3[CH:37]=[C:36](Br)[CH:35]=[CH:34][C:33]=3[F:39])([CH3:31])[N:30]=2)([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=2)[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:5][CH:4]=1.[CH3:41][C:42]1[CH:43]=[N:44][NH:45][CH:46]=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([NH:24][C:25]2[O:26][CH2:27][C@H:28]([F:40])[C@:29]([C:32]3[CH:37]=[C:36]([N:44]4[CH:43]=[C:42]([CH3:41])[CH:46]=[N:45]4)[CH:35]=[CH:34][C:33]=3[F:39])([CH3:31])[N:30]=2)([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=2)[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:5][CH:4]=1