HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-1-(2,2-difluoro-ethyl)-1H-pyrazole-3-carboxylic acid methoxy-methyl-amide → 1-(4-Chloro-1-(2,2-difluoroethyl)-1H-pyrazol-3-yl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-1-(2,2-difluoro-ethyl)-1H-pyrazole-3-carboxylic acid methoxy-methyl-amide | HCID 86673731 | — |
| Reactant | HCID 178418573 | HCID 178418573 | — |
| Product | 1-(4-Chloro-1-(2,2-difluoroethyl)-1H-pyrazol-3-yl)ethanone | HCID 71008659 | 66% |
Reaction Steps
In a manner analogous to that described in Example 14 b), the Grignard reaction of 4-chloro-1-(2,2-difluoro-ethyl)-1H-pyrazole-3-carboxylic acid methoxy-methyl-amide with methylmagnesium bromide yielded the title compound (66% yield) as a colorless oil. MS (ISP): m/z=209.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08785436B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-e8e9545f6cb5421888d16489d0930898 |
| Source note | uspto-grants-2014_07 |