HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanamine, N-methoxy-, hydrochloride (1:1) → 5-cyclopropyl-N-methoxy-N-methylisoxazole-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| Reactant | 5-Cyclopropyl-1,2-oxazole-3-carboxylic acid | HCID 1092113 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Product | 5-cyclopropyl-N-methoxy-N-methylisoxazole-3-carboxamide | HCID 60717482 | 96% |
Reaction Steps
In a manner analogous to that described in Example 1 d), the condensation of 5-cyclopropyl-isoxazole-3-carboxylic acid and N,O-dimethylhydroxylamine hydrochloride by N-(3-dimethylaminopropyl)-N′-ethyl-carbodiimide hydrochloride yielded the title compound (96% yield) as a pale yellow oil. MS (ISP): m/z=197.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08785436B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-a6defda38065440188ec306287807a4a |
| Source note | uspto-grants-2014_07 |