5-Chloropyridine-3-boronic acid → HCID 71008875, compound

HRID 1626137Notes

Reaction equation

HRID 1626137 reaction equation
Br[C:2]1[C:3]([F:19])=[CH:4][C:5]([F:18])=[C:6]([C@:8]2([CH3:17])[C:13]([F:15])([F:14])[CH2:12][O:11][C:10]([NH2:16])=[N:9]2)[CH:7]=1.[Cl:20][C:21]1[CH:22]=[C:23](B(O)O)[CH:24]=[N:25][CH:26]=1>>[Cl:20][C:21]1[CH:22]=[C:23]([C:2]2[C:3]([F:19])=[CH:4][C:5]([F:18])=[C:6]([C@:8]3([CH3:17])[C:13]([F:15])([F:14])[CH2:12][O:11][C:10]([NH2:16])=[N:9]3)[CH:7]=2)[CH:24]=[N:25][CH:26]=1

Participants

3

Reactant 2

HCID 201118775-Chloropyridine-3-boronic acidHCID 71009078HCID 71009078, compound

Product 1

HCID 71008875HCID 71008875, compound

Procedure

In a manner analogous to that described in Example 31, the cross-coupling reaction of (R)-4-(5-bromo-2,4-difluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate A6.2) and 5-chloropyridin-3-ylboronic acid yielded the title compound as a pale yellow solid. MS (ISP): m/z=373.8 [M+H]+.

Sources & evidence

ORD record
ord-1ca617f8568d4922862ccd46d5854bf4
Source dataset
uspto-grants-2014_07
Patent number
US08785436B2

Reaction notes

Loading…