5-Chloropyridine-3-boronic acid → HCID 71008931, compound

Participants

Reaction Steps

In a manner analogous to that described in Example 9 a), the cross-coupling reaction of [bis-(4-methoxy-phenyl)-phenyl-methyl]-[(R)-4-(5-bromo-2-fluoro-phenyl)-5,5-difluoro-4,6,6-trimethyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-amine (intermediate C4.1) with 5-chloropyridin-3-ylboronic acid yielded the title compound (86% yield) as a white solid. MS (ISP): m/z=686.3 [M+H]+.

Provenance & Evidence