3,5-Dichlorophenylboronic acid → HCID 71009153, compound

Participants

Reaction Steps

In a manner analogous to that described in Example 9 a), the cross-coupling reaction of [bis-(4-methoxy-phenyl)-phenyl-methyl]-[(R)-4-(5-bromo-2-fluoro-phenyl)-5,5-difluoro-4,6,6-trimethyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-amine (intermediate C4.1) with 3,5-dichlorophenylboronic acid yielded the title compound (80% yield) as a white foam. MS (ISP): m/z=719.4 [M+H]+ and 721.0 [M+H]+.

Provenance & Evidence