Trifluoroacetic acid → HCID 71008725, compound

Participants

Reaction Steps

In a manner analogous to that described in Example 62.1b), the deprotection of {(R)-4-[(1R,2R)-2-(6-Cyano-thieno[3,2-b]pyridin-3-ylcarbamoyl)-cyclopropyl]-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl}-carbamic acid tert-butyl ester with trifluoroacetic acid yielded the title compound (59% yield) as a light yellow solid. MS (ISP): m/z=392.2 [M+H]+.

Provenance & Evidence