Iodine → HCID 86666998, compound

HRID 1626236Notes

Reaction equation

HRID 1626236 reaction equation
[Cl:1][C:2]1[C:15]2[NH:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[S:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[I:16]I>C(Cl)(Cl)Cl>[I-:16].[Cl:1][C:2]1[C:15]2[C:6](=[S+:7][C:8]3[C:13]([N:14]=2)=[CH:12][CH:11]=[CH:10][CH:9]=3)[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 807IodineHCID 3509221-chloro-10H-phenothiazine

Product 1

HCID 86666998HCID 86666998, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Conditions

Temperature
5 °C

Procedure

1-Chlorophenothiazine (664 mg, 2.84 mmol) was dissolved in CHCl3 (50 mL) and cooled to 5° C. The solution was stirred as a solution of I2 (2.16 g, 8.51 mmol) dissolved in CHCl3 (10 mL) was added dropwise. The mixture was stirred at 5° C. overnight and allowed to warm to RT. The solvent was evaporated to dryness. The residue was stirred in Et2O and was filtered off and washed with Et2O until the filtrate was colorless. The dark solid was dried under vacuum and used without purification.

Workup

  1. additionwas added dropwise
  2. temperatureto warm to RT
  3. customThe solvent was evaporated to dryness
  4. stirringThe residue was stirred in Et2O
  5. filtrationwas filtered off
  6. washwashed with Et2O until the filtrate
  7. customThe dark solid was dried under vacuum
  8. customused without purification

Sources & evidence

ORD record
ord-7f0bcd1bd2db43f7a62b9a21ad4fc290
Source dataset
uspto-grants-2014_07
Patent number
US08785434B2

Reaction notes

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