Iodine → HCID 87410566, compound

HRID 1626238Notes

Reaction equation

HRID 1626238 reaction equation
[CH2:1]([C:3]1[C:16]2[NH:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[S:8][C:7]=2[CH:6]=[CH:5][CH:4]=1)[CH3:2].[I:17]I>C(Cl)(Cl)Cl>[I-:17].[CH2:1]([C:3]1[C:16]2[C:7](=[S+:8][C:9]3[C:14]([N:15]=2)=[CH:13][CH:12]=[CH:11][CH:10]=3)[CH:6]=[CH:5][CH:4]=1)[CH3:2]

Participants

4

Reactant 2

HCID 807IodineHCID 525754610H-Phenothiazine, 1-ethyl-

Product 1

HCID 87410566HCID 87410566, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Conditions

Temperature
5 °C

Procedure

1-Ethylphenothiazine (664 mg, 2.84 mmol) was dissolved in CHCl3 (50 mL) and cooled to 5° C. The solution was stirred as a solution of I2 (2.16 g, 8.51 mmol) dissolved in CHCl3 (10 mL) was added dropwise. The mixture was stirred at 5° C. overnight and allowed to warm to RT. The solvent was evaporated to dryness. The residue was stirred in Et2O and was filtered off and washed with Et2O until the filtrate was colorless. The dark solid was dried under vacuum and used without purification.

Workup

  1. additionwas added dropwise
  2. temperatureto warm to RT
  3. customThe solvent was evaporated to dryness
  4. stirringThe residue was stirred in Et2O
  5. filtrationwas filtered off
  6. washwashed with Et2O until the filtrate
  7. customThe dark solid was dried under vacuum
  8. customused without purification

Sources & evidence

ORD record
ord-cb18f1e71c40427aa6622efbd58cdc15
Source dataset
uspto-grants-2014_07
Patent number
US08785434B2

Reaction notes

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