Cesium carbonate → 3-(4-Methylpiperazin-1-yl)-7-(pyrrolidin-1-yl)-1-trifluoromethyl-10-Boc-phenothiazine

Participants

Reaction Steps

To a stirred solution of 7-(pyrrolidin-1-yl)-3-bromo-1-trifluoromethyl-10-Boc-phenothiazine (30 mg, 0.058 mmol) in xylenes (5 mL) Pd(dba)2 (1.7 mg, 0.003 mmol), BINAP (1.3 mg, 0.002 mmol), Cs2CO3 (94.5 mg, 0.29 mmol) and 1-methylpiperazine (8.7 mg, 0.01 mL, 0.087 mmol) were added. The mixture was refluxed for 48 h. After that reaction mixture was filtered, solvent was removed under vacuum. Product was used without additional purification.

Provenance & Evidence