Diethyl Ether → HCID 5257545, compound

Participants

Reaction Steps

To a solution of 2-chlorophenothiazine (4.67 g, 20 mmol) in anhydrous ethyl ether (60 mL) methyllithium (1.6 m solution, 62.5 mL, 0.1 mole) was added at room temperature (1 h). After that the mixture had been stirred (6 h), ice-water was added slowly, the stirring was continued for 30 min. The organic layer was separated and combined with ether extracts of the aqueous phase. The combined organic phase was washed with water, dried (Na2SO4) and concentrated to give the crude product (37% yield). Compound was purified by flash chromatography.

Provenance & Evidence