Methanol → HCID 178448938, compound

HRID 1626260Notes

Reaction equation

HRID 1626260 reaction equation
[I-:1].[I-].[I-].[C:4]([N:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:14]=[C:15]([CH3:28])[C:16]3[C:25]([CH:26]=2)=[S+:24][C:23]2[C:18](=[C:19]([CH3:27])[CH:20]=[CH:21][CH:22]=2)[N:17]=3)[CH2:9][CH2:8]1)(=[O:6])[CH3:5].C(N1CC[N:35]([C:38]2C=C(C)[C:41]3[C:50]([CH:51]=2)=[S+]C2C(=C(C)C=CC=2)N=3)[CH2:34]C1)(=O)C.C(N1CCN(C2C=C(C)C3C(C=2)=[S+]C2C(=C(C)C=CC=2)N=3)CC1)(=O)C.CO>>[I-:1].[C:4]([N:7]1[CH2:8][CH2:9][N:10]([C:13]2[CH:14]=[C:15]([CH3:28])[C:16]3[C:25]([CH:26]=2)=[S+:24][C:23]2[C:18](=[C:19]([CH3:27])[CH:20]=[C:21]([N:35]([CH3:34])[CH2:38][CH2:51][CH2:50][CH3:41])[CH:22]=2)[N:17]=3)[CH2:11][CH2:12]1)(=[O:6])[CH3:5]

Participants

3

Reactant 2

HCID 887MethanolHCID 178473879HCID 178473879, compound

Product 1

HCID 178448938HCID 178448938, compound

Procedure

To a solution of 3-(4-acetylpiperazin-1-yl)-1,9-dimethylphenothiazin-5-ium triiodide (73 mg, 0.1 mmol) in methanol (5 mL) methyl(n-butyl)amine (0.034 mL, 25.2 mg, 0.3 mmol) was added. Reaction mixture was stirred for 24 h at room temperature. The resulting mixture was concentrated to dryness and purified by flash chromatography using the methanol-chloroform gradient to provide the title compound.

Workup

  1. customReaction mixture
  2. concentrationThe resulting mixture was concentrated to dryness
  3. custompurified by flash chromatography

Sources & evidence

ORD record
ord-eddc34ef0d2843efb35c9ea6d6f422e6
Source dataset
uspto-grants-2014_07
Patent number
US08785434B2

Reaction notes

Loading…