1-Acetylpiperazine → HCID 178473880, compound

HRID 1626261Notes

Reaction equation

HRID 1626261 reaction equation
[I-:1].[I-].[I-].[C:4]([N:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:14]=[C:15]([CH3:28])[C:16]3[C:25]([CH:26]=2)=[S+:24][C:23]2[C:18](=[C:19]([CH3:27])[CH:20]=[CH:21][CH:22]=2)[N:17]=3)[CH2:9][CH2:8]1)(=[O:6])[CH3:5].[C:29]([N:32]1[CH2:37][CH2:36][N:35](C2C=C(C)C3C(C=2)=[S+]C2C(=C(C)C=CC=2)N=3)[CH2:34][CH2:33]1)(=[O:31])[CH3:30].C(N1CCN(C2C=C(C)C3C(C=2)=[S+]C2C(=C(C)C=CC=2)N=3)CC1)(=O)C.C(N1CCNCC1)(=O)C>CO>[I-:1].[C:29]([N:32]1[CH2:37][CH2:36][N:35]([C:21]2[CH:20]=[C:19]([CH3:27])[C:18]3[C:23]([CH:22]=2)=[S+:24][C:25]2[C:16](=[C:15]([CH3:28])[CH:14]=[C:13]([N:10]4[CH2:9][CH2:8][N:7]([C:4](=[O:6])[CH3:5])[CH2:12][CH2:11]4)[CH:26]=2)[N:17]=3)[CH2:34][CH2:33]1)(=[O:31])[CH3:30]

Participants

4

Reactant 2

HCID 837951-AcetylpiperazineHCID 178473879HCID 178473879, compound

Product 1

HCID 178473880HCID 178473880, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 3-(4-acetylpiperazin-1-yl)-1,9-dimethylphenothiazin-5-ium triiodide (73 mg, 0.1 mmol) in methanol (5 mL) and 1-acetylpiperazine (38.5 mg, 0.3 mmol) was stirred for 24 h at room temperature. The resulting mixture was concentrated to dryness and purified by flash chromatography using the methanol-chloroform gradient to provide the title compound.

Workup

  1. concentrationThe resulting mixture was concentrated to dryness
  2. custompurified by flash chromatography

Sources & evidence

ORD record
ord-8f2163ef9220474ea888ef00d3e5f320
Source dataset
uspto-grants-2014_07
Patent number
US08785434B2

Reaction notes

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