Sodium Hydroxide → HCID 68649743, compound

HRID 1626287Notes

Reaction equation

HRID 1626287 reaction equation
C([O:3][C:4](=[O:18])[C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:16][CH2:15][CH:14]([F:17])[CH2:13][CH2:12]2)=[CH:7][CH:6]=1)C.[OH-].[Na+]>C(O)C>[F:17][CH:14]1[CH2:13][CH2:12][N:11]([C:8]2[CH:9]=[CH:10][C:5]([C:4]([OH:18])=[O:3])=[CH:6][CH:7]=2)[CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 686494674-(4-Fluoropiperidin-1-yl)benzoic acid ethyl ester

Product 1

HCID 68649743HCID 68649743, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 4-(4-fluoro-piperidin-1-yl)benzoic acid ethyl ester (0.7 g, 2.7 mmoles) in ethanol (50 ml) and a solution of 2N sodium hydroxide (20 ml) was stirred at room temperature for 24 hours. The ethanol was then evaporated, the solution diluted with water (20 ml) and neutralized with 2N HCl. The acid separated as a white solid which was washed with water and dried under vacuum (0.52 g, 82%).

Workup

  1. customThe ethanol was then evaporated
  2. additionthe solution diluted with water (20 ml)
  3. customThe acid separated as a white solid which
  4. washwas washed with water
  5. customdried under vacuum (0.52 g, 82%)

Sources & evidence

ORD record
ord-36ec72dd1a7448df8f357a2a7d281898
Source dataset
uspto-grants-2014_07
Patent number
US08785448B2

Reaction notes

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