Methyl iodide → HCID 58358782, compound

Participants

Reaction Steps

To the solution of benzyl 3-(tert-butyldimethylsilyloxy)propylcarbamate obtained in step 2 (5 g, 15.5 mmol) in tetrahydrofuran (20 ml), sodium hydride (1.24 g, 31 mmol, 60% in mineral oil) and iodomethane (3.86 ml, 62 mmol) were added slowly. The reaction temperature was warmed up to room temperature, and stirred for overnight. The reaction was completed quenched by water and organic material was extracted with ether. After evaporation of volatile material under reduced pressure, the residue was purified with silica gel column chromatography (EtOAC:Hx=1:10) to give the title compound (4.9 g, 94%) as light yellow oil.

Provenance & Evidence