Benzoyl chloride → HCID 86670632, compound

Participants

Reaction Steps

6-chloro-N4-phenylpyrimidine-4,5-diamine obtained in step 1 (35 g, 158.6 mmol) was dissolved in N,N-dimethylacetamide (265 ml) at 0° C. Benzoyl chloride (20.5 mL, 174.5 mmol) was added slowly to the resulting solution at 0° C. and warmed to room temperature. The reaction mixture thus obtained was stirred for 4 hours at room temperature and filtered with NaHCO3(aq)/H2O. The collected solid was dried under reduced pressure to obtain the title compound (50.1 g, 97%) as white solid.

Provenance & Evidence