反应详情

To a stirred solution of ethyl 4-aminobenzoate (5 gm, 30.3 mmol) under nitrogen atmosphere was added pyridine (50 ml) at 0° C. and stirred for 10 min. Quinoline-8-sulfonyl chloride 89 (8.94 gm, 39.4 mmol) was then added to the reaction mixture at the same temperature. The resulting mixture was stirred for 16 hr at RT. After completion of the reaction, the solvent was removed under low pressure. The traces of pyridine were removed by co-distillation with toluene. Diethylether was added to the resulting residue, and the solid product was filtered out and air-dried. The resulting crude product (8.0 gm, 74%) was taken to the next step without further purification.

1. stirringThe resulting mixture was stirred for 16 hr at RT
2. customAfter completion of the reaction
3. customthe solvent was removed under low pressure
4. customThe traces of pyridine were removed by co-distillation with toluene
5. additionDiethylether was added to the resulting residue
6. filtrationthe solid product was filtered out and
7. customair-dried
8. customThe resulting crude product (8.0 gm, 74%) was taken to the next step without further purification