Tert-butyl 7-(4-(5-chloropyridin-2-ylcarbamoyl)phenoxy)-6-cyanochroman-4-carboxylate → 7-(4-(5-Chloropyridin-2-ylcarbamoyl)phenoxy)-6-cyanochroman-4-carboxylic acid

Participants

Reaction Steps

tert-Butyl 7-(4-(5-chloropyridin-2-ylcarbamoyl)phenoxy)-6-cyanochroman-4-carboxylate (4 mg, 0.0079 mmol) was diluted with DCM (500 μL) and TFA (500 μL). After stirring for 2 hours, the reaction was concentrated and placed under high vacuum for 1 hour. The residue was purified by preparative TLC, eluting with 10% methanol/DCM to provide the desired product (2.5 mg, 0.0056 mmol, 70% yield) as a white solid. MS (ESI)=450.1 (M+1).

Provenance & Evidence