Hydrochloric Acid → HCID 67288840, compound

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Reaction Steps

A mixture of methyl 6-cyano-7-(4-(6-(3,4-dimethylphenyl)pyridin-2-ylcarbamoyl)phenoxy)chroman-4-carboxylate (51.1 mg, 0.096 mmol), LiOH—H2O-1M−H2O (191.5 μL, 0.1915 mmol), and THF (1.5 mL) was stirred at ambient temperature for 3 days. The mixture was quenched with HCl (4M in dioxane) (71.83 μL, 0.287 mmol). The crude material was purified by silica gel column chromatography to provide the desired product (0.027 g). MS (APCI)=520.2 (M+1).

Provenance & Evidence