Lithium hydroxide, monohydrate → HCID 67287160, compound

Participants

Reaction Steps

To a solution of methyl 6-cyano-7-(2-methyl-4-(6-(trifluoromethyl)pyridin-3-ylcarbamoyl)phenoxy)chroman-4-carboxylate (0.097 g, 0.190 mmol) in 2 mL of THF containing 200 μL methanol was added LiOH—H2O (0.379 mL, 0.379 mmol) and the solution was stirred at ambient temperature for 12 hours. The reaction was quenched with 1 drop of glacial acetic acid and then concentrated to dryness. The crude material was purified by silica gel column chromatography, eluting with 2-5% methanol/dichloromethane+0.1% acetic acid to provide the desired product (0.04 g, 42%). MS (APCI)=498.1 (M+1).

Provenance & Evidence