Ethanol → HCID 46701752, compound

Participants

Reaction Steps

Ethyl 6-chloro-7-(4-(6-chloroquinoxalin-2-ylcarbamoyl)phenoxy)chroman-4-carboxylate (540 mg, 1.00 mmol) was diluted with THF (8 mL) followed by the addition of NaOH (5015 μL, 5.02 mmol) and ethanol (4 mL). After stirring for 2 hours, the reaction was diluted with ethyl acetate and 0.5 M HCl. The layers were separated and the organic layer was dried over MgSO4, filtered and concentrated. The material was triturated with DCM to provide the desired product (420 mg, 0.823 mmol, 82.1% yield). MS (ESI)=510.1 (M+1).

Provenance & Evidence