Triethylamine → HCID 67287501, compound

Participants

Reaction Steps

A mixture of 4-(6-cyano-4-(methoxycarbonyl)chroman-7-yloxy)benzoic acid (20 mg, 0.0566 mmol), 1-(3-(dimethylamino)propyl)-3-ethyl-carbodiimide hydrochloride (12.85 mg, 0.0670 mmol), 1-hydroxybenzotriazole monohydrate (10.26 mg, 0.0670 mmol), and 1,2-dichloroethane (1 mL) was stirred at ambient temperature for 20 minutes. 2-(5-(Trifluoromethyl)pyridin-2-yl)ethanamine dihydrochloride (19.23 mg, 0.0731 mmol) and triethylamine (84.91 μl, 0.6092 mmol) were added to the activated acid and the mixture was stirred for 18 hours at ambient temperature. The reaction mixture was purified on silica gel (MeOH in dichloromethane gradient) to provide 14.2 mg of the title compound as a thin film (48%).

Provenance & Evidence