Hydrochloric Acid → HCID 67288468, compound

Participants

Reaction Steps

Methyl 6-cyano-7-(4-(2-(5-(trifluoromethyl)-pyridin-2-yl)ethylcarbamoyl)phenoxy)chroman-4-carboxylate (14.2 mg, 0.0270 mmol) was dissolved in THF (3 mL) and 1M solution of lithium hydroxide monohydrate in water (54.0 μl, 0.0540 mmol) was added. The mixture was stirred overnight at ambient temperature, then quenched with 4.0 M HCl solution in 1,4-dioxane (20.3 μl, 0.0811 mmol). The reaction mixture was purified on silica gel (MeOH in dichloromethane with 1% acetic acid gradient) to provide 5.1 mg of the title compound as a thin film (37%). MS (apci) m/z=509.7 (M−H).

Provenance & Evidence