Hydrochloric Acid → HCID 67288840, compound

Participants

Reaction Steps

A mixture of methyl 6-cyano-7-(4-(6-(3,4-dimethylphenyl)pyridin-2-ylcarbamoyl)phenoxy)-chroman-4-carboxylate (51.1 mg, 0.09577 mmol), 1.0 M lithium hydroxide monohydrate solution in water (191.5 μl, 0.1915 mmol), and THF (1.5 ml) was stirred for 3 days at ambient temperature. The mixture was quenched with 4.0 M HCl solution in 1,4-dioxane (71.83 μl, 0.2873 mmol). The mixture was purified on silica gel (MeOH in dichloromethane gradient with 1% acetic acid) to provide 42.8 mg of the title compound was obtained as a thin film (86%). MS (apci) m/z=520.2 (M+H).

Provenance & Evidence