Sodium Methoxide → HCID 67287648, compound

HRID 1626439Notes

Reaction equation

HRID 1626439 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19](=[O:38])[NH:20][C:21]3[N:22]=[N:23][C:24]([C:27]4[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][C:28]=4[Cl:37])=[CH:25][CH:26]=3)=[CH:15][CH:14]=1)[O:8][CH2:7][CH2:6][CH:5]2[C:39]([OH:41])=[O:40].C[O-].[Na+:44]>CO>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19](=[O:38])[NH:20][C:21]3[N:22]=[N:23][C:24]([C:27]4[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:34])[F:35])=[CH:29][C:28]=4[Cl:37])=[CH:25][CH:26]=3)=[CH:15][CH:14]=1)[O:8][CH2:7][CH2:6][CH:5]2[C:39]([O-:41])=[O:40].[Na+:44]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 67287448HCID 67287448, compound

Product 1

HCID 67287648HCID 67287648, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of 6-chloro-7-(4-(6-(2-chloro-4-(trifluoromethyl)phenyl)pyridazin-3-ylcarbamoyl)phenoxy)chroman-4-carboxylic acid (0.030 g, 0.050 mmol) in MeOH (2 ml) was added a 0.5M solution of sodium methoxide in methanol (0.099 ml, 0.050 mmol), and the reaction was stirred for 2 hours. The reaction was concentrated to yield the desired compound (0.030 g, 0.048 mmol, 96% yield). MS (apci) m/z=603.9 (M-Na+2H).

Workup

  1. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-ae058d5ba06447fab8c9d839e9ebdb7e
Source dataset
uspto-grants-2014_07
Patent number
US08785445B2

Reaction notes

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