1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 67288339, compound

Participants

Reaction Steps

2-(2-Methoxy-6-(trifluoromethyl)pyridin-3-yl)ethanamine (140 mg, 0.637 mmol) in dichloromethane (1 ml) was treated sequentially with 4-(6-chloro-4-(ethoxycarbonyl)chroman-7-yloxy)benzoic acid (Preparation B; 240 mg, 0.637 mmol), N1-((ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine hydrochloride (147 mg, 0.764 mmol), and 4-(dimethylamino)pyridine (7.78 mg, 0.0637 mmol) at ambient temperature. After 14 hours, the reaction was applied directly to silica gel. Elution with ethyl acetate (50-80%) provided the desired compound (264 mg, 0.456 mmol, 71.6% yield) as a white solid.

Provenance & Evidence