Methanol → HCID 67287941, compound

Participants

Reaction Steps

6-Chloro-7-(4-(2-(2-methoxy-6-(trifluoromethyl)pyridin-3-yl)ethylcarbamoyl)phenoxy)chroman-4-carboxylic acid (255 mg, 0.463 mmol) in 2:1 THF-MeOH (2 ml) was treated with 0.5 N sodium methoxide in methanol (926 μl, 0.463 mmol) at ambient temperature. After 15 minutes, the reaction was concentrated in vacuo. The material was suspended in ethyl acetate and concentrated to a solid. The solid was suspended in ethyl acetate, hexanes were added, and the mixture was concentrated in vacuo to a solid. The material was suspended in dichloromethane, hexanes were added, and the suspension concentrated to provide the desired compound (268 mg, 0.468 mmol, 101% yield) as a solid. MS (apci) m/z=551.0 (M-Na+2H).

Provenance & Evidence