Ethanol → HCID 67288893, compound

Participants

Reaction Steps

Ethyl 6-chloro-7-(4-(2-(3-chlorophenyl)pyrimidin-5-ylcarbamoyl)phenoxy)chroman-4-carboxylate (45 mg, 0.080 mmol) was diluted with THF (1 mL) followed by the addition of NaOH (399 μl, 0.40 mmol) and ethanol (500 uL). After stirring for 2 hours, the reaction was diluted with ethyl acetate and 2N HCl. The layers were separated and the organic layer was dried over MgSO4, filtered and concentrated. The residue was purified using a 0.5 mm preparative TLC plate eluting with 10% methanol/DCM to yield the desired compound (15 mg, 0.028 mmol, 35% yield) MS (ESI)=536.1 (M+H).

Provenance & Evidence