Methanol → HCID 67287832, compound

Participants

Reaction Steps

Methyl 6-cyano-7-(4-(5-phenyl-1,3,4-thiadiazol-2-ylcarbamoyl)phenoxy)chroman-4-carboxylate (17 mg, 0.033 mmol) was diluted with THF (500 μL) followed by the addition of NaOH (166 μL, 0.17 mmol) and methanol (200 μL). After stirring for 2 hours, the reaction was diluted with ethyl acetate and 2N HCl. The layers were separated and the organic layer was dried over MgSO4, filtered and concentrated to yield 6-cyano-7-(4-(5-phenyl-1,3,4-thiadiazol-2-ylcarbamoyl)phenoxy)chroman-4-carboxylic acid (10 mg, 0.020 mmol, 60% yield). MS (APCI)=498.9 (M+1).

Provenance & Evidence